The present study was intended to assess the hepatoprotective potential of caralluma umbellata haw. Learn more about caralluma uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain caralluma. Hepatoprotective effect of caralluma umbellate against. Message the user has shared this species from india biodiversity portal with you. To find out a scientific validation for the traditional knowledge of tribals of chittoor district, india for their usage of caralluma umbellata haw to cure stomach disorder and pain. Paulraj 1 department of botany, nesamony memorial christian college, marthandam, tamilnadu, india department of botany, scott christian college autonomous, nagercoil, tamilnadu, india.
Us7390516b2 caralluma extract products and processes for. The molecular weight of cup is found to be less than that of hrp 44 kda. In the first caralluma extract, the resinous material does not exceed 0. Evaluation of cytotoxicity in selected species of caralluma and boucerosia madhuri vajha 1 and chillara siva rama krishna 2 1department of biotechnology, krishna university, machilipatnam 2department of pharmacognosy, laila nutraceuticals, vijayawada, andhra pradesh, india.
This study is designed to evaluate antihyperglycemic activity of caralluma umbellata haw, which is used as a traditional medicinal plant all over india through in vitro studies. Caralluma umbellata is known as a valuable medicinal plant. Files are available under licenses specified on their description page. It is also found in the wild in africa, saudi arabia, canary islands, afghanistan, and southern europe.
The in vitro antioxidant activity was tested on superoxide, hydroxyl and dpph free radicals. Methanolic, aqueous and hydro methanolic extracts of caralluma umbellata were. Crur i and crur ii figure 27 were isolated from the roots of caralluma umbellata kishore et al. Caralluma europaea is a low perennial stem succulent forming mats by means of long stolons running underground, as the name suggests, it is a species of special interest, because it one of the two european species the other being caralluma munbyana.
The histochemical and zymographic studies along with in vitro pod activity assay with various substrates substantiate the presence of peroxidase. A study of phytochemical constituents in caralluma umbellata by gc ms anaylsis pdf. Caralluma umbellata haw grows wild in dry and arid regions of chittoor district and several districts of andhra pradesh, in india. Cordelly mullangi ramesh a billa srilatha a bommineni reddy a achanta venkata. The aim of this study was to investigate the effects of caralluma russeliana stem extract on some physiological parameters in. An international journal of pharmaceutical science on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. A medicinal importance and chemical composition of. Caralluma umbellata is a succulent plant spices, which belongs to asclepiadaceous family. A study of phytochemical constituents in caralluma. Till the date more than 26 variety of medicinally important chemicals are isolated by different methodologies.
Arunkumar and muthuselvam 2009 reported in the gcms analysis 26bioactive phytochemical compounds were identified in. A caralluma extract and a method of making thereof which can be standardized and reproducible, and which prevents the glycosides from decomposition, which can reduce the undesirable nonglycoside components. To evaluate the hepatoprotective activity of ethanolic extracts of caralluma umbellata haw. Us7390516b2 us11083,226 us8322605a us7390516b2 us 7390516 b2 us7390516 b2 us 7390516b2 us 8322605 a us8322605 a us 8322605a us 7390516 b2 us7390516 b2 us 7390516b2 authority us united states prior art keywords caralluma extract caralluma extract content solvent prior art date 20030604 legal status the legal status is an assumption and is not a legal conclusion.
Pdf antiinflammatory activity of carumbellosideiii. Caralluma fimbriyata an edible succulent cactus is a perennial herb growing in dry parts of tamil nadu, india. Author links open overlay panel leejuian lin 1 longze lin roberto r. The extracts were evaluated for glucose uptake in l6 myotubes in vitro.
It is cooked as a vegetable and is used in preserves such as chutneys and pickles. It is a thick, erect, leafless, branching, and succulent a. The results of present study shows caralluma umbellata has potential antidiabetic property, thus. Br which will help in dosage fixation for further exploration of their therapeutic efficacy. Modern practice of gas chromatography, fourth edition. Within the caralluma genus, caralluma tuberculata, caralluma sinaica, caralluma umbellata haw, and caralluma fimbriata have all been proven to have antidiabetic properties. Caralluma umbellata and to study its potential as an antibacterial and antifungal agent. Keywords caralluma fimbriata, appetite suppressant, safety assessment. Cistanthe umbellata also calyptridium umbellatum is a species of flowering plant in the montia family known by the common name mount hood pussypaws or especially outside the pacific northwest simply pussypaws. This is the first report of peroxidase derived from caralluma umbellata. Phytochemistry the international journal of plant biochemistry. Extracts were studied for their toxicity by mtt and trypan blue dye exclusion models against a panel of cancer, normal origin cell lines. The results of present study shows caralluma umbellata has potential antidiabetic property, thus providing a further scope for study. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats.
Caralluma is a xerophytic genus used as traditional medicine for the treatment of diabetes, inflammation, leprosy, obesity and rheumatism. The subjects were either given a placebo or 500 mg of caralluma extract 2 times a day for 12 weeks caralluma adscendens roxb. Carumbelloside iv was evaluated in wistar rats using carraeenan induced left hind paw edema model. The flowers are very variable throughout the vast distribution range, 6 to 25 cm in diameter, variably hairy and uniformly coloured. Effects of caralluma russeliana stem extract on some physiological parameters in streptozotocininduced diabetic male rats talal a zari, mesfer a althebaiti department of biological sciences, faculty of science, king abdulaziz university, jeddah, saudi arabia purpose. It has varied medicinal properties that can be exploited for the treatment of many diseases. The theistic doctrine of liberation is presented on the basis of relation between the lord and the individual self. Methanolic, aqueous and hydro methanolic extracts of caralluma umbellata were prepared and studied for their anti hyperglycemic activity. Safety assessment of a hydroethanolic extract of caralluma fimbriata. Phytochemical study on antioxidant and antiproliferative. The result clearly indicates that caralluma umbellata has varied medicinal properties that can be exploited for the treatment of many diseases table 2. Br, caralluma attenuate wight, caralluma umbellata haw and caralluma diffusa wight n. Safety assessment of a hydroethanolic extract of caralluma.
Preliminary analysis for antioxidant and hepatoprotective property. However the toxicity of a plant has to be studied for further exploration of various biological activities. A study of antiinflammatory activity of one novel c21 steroidal glycoside known as carumbellosideiv isolated from caralluma umbellata sayantan ray1, k nagaiah2, nawaz f khan3 1nshm college of pharmaceutical technology, kolkata, west bengal, india 2school of science and humanities, vit university, vellore, tamil nadu, india. In india it grows wild and is often used as a border in gardens and as a roadside shrub. Phytochemical and ftir spectral analysis of caralluma geniculata grev. Nephroprotective and antioxidant activities of caralluma umbellata. The phytochemical analysis showed the presence of potent phytochemicals like flavanoids, terpenoids, tannius, glycosides sterols, phenols and saponins. Antihyperglycemic activity of caralluma umbellata haw. Fourier transform infrared spectroscopy analysis of. This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from caralluma fimbriata cfe, a dietary supplement marketed worldwide as an appetite suppressant. A study of antiinflammatory activity of one novel c21. Pdf vast applications of peroxidases create an increasing demand to. Antiinflammatory activity of carumbellosideiii, isolated from caralluma umbellate.
Its activity is dependent on hydrogen peroxide and has an optimum ph and temperature of 6. The plant caralluma adscendens has been used in different system of. It is medicinally important and rich in pregnane glycosides, which may. Us7060308b2 caralluma extract products and processes for. All structured data from the file and property namespaces is available under the creative commons cc0 license. From caralluma umbellata, two new pregnane glycosides, named carumbelloside i and ii, were isolated and their structures and. Evidence for peroxidase activity in caralluma umbellata. Caralluma umbellata peroxidase cup is an acidic hemecontaining protein having a molecular weight of 42 kda and is specific to guaiacol. This study is designed to evaluate antihyperglycemic activity of caralluma umbellata haw, which is used as a. Phytochemical and ftir spectral analysis of caralluma. Pdf antihyperglycemic activity of caralluma umbellata haw.
Hepatoprotective effect of caralluma umbellate against acetaminophen induced oxidative stress and. The phytochemical study using caralluma umbellate asclepiadaceae whole plant allowed the isolation of a novel c21 steroidal glycoside, named as carumbellosideiv. The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of c. Steroidal glycosides from caralluma umbellata sciencedirect.
Nephroprotective and antioxidant activities of caralluma. Paracetamol is a potent hepatotoxin and may cause severe acute hepatocellular injury. Citeseerx document details isaac councill, lee giles, pradeep teregowda. Caralluma species have been reported for various traditional claims. The phytochemical screening was carried out using standard phytochemical tests. Caralluma umbellata is a succulent plant spices, which belongs to.
Pregnane glycosides from caralluma umbellata sciencedirect. Evaluation of in vitro antibacterial activity of caralluma. Download fulltext pdf evidence for peroxidase activity in caralluma umbellata article pdf available in applied biochemistry and biotechnology 1738. Caralluma is a genus of flowering plants in the family apocynaceae, consisting of about 120. Their structures were elucidated by extensive nmr spectroscopic studies devoid of any.
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